Hu Xiaofen, Ph.D., Master Supervisor, is an Associate Professor at the College of Animal Science and Technology, Jiangxi Agricultural University. Her primary research fields include gene editing, embryonic development, and animal disease prevention and control.
Involved Projects and Grants:
1. National Natural Science Foundation of China, 32160138 - “Studies on cell profiles construction and key gene regulatory network of compound eye development in honeybee” (2022-01-01 to 2025-12-31, ¥350,000, ongoing, Principal Investigator).
2. Jiangxi Provincial Science and Technology Department, Science and Technology Research Project, 20242BAB25392 - “Innovative study on the identification of major genes for embryonic development and early differentiation mechanisms of honeybee hypopharyngeal glands (HGs) based on CRISPR/Cas9 technology” (2024-06-01 to 2027-05-31, ¥100,000, ongoing, Principal Investigator).
3. Jiangxi Provincial Science and Technology Department, Science and Technology Research Project, 20202BABL205007 - “Functional study on sex determination related genes Fem and Amtra2 based on CRISPR/Cas9 technology” (2020-01 to 2022-12, ¥30,000, completed, Principal Investigator).
4. Jiangxi Provincial Department of Education, Science and Technology Research Project, GJJ190193 - “Functional Study of Honeybee Pax6 Gene Based on CRISPR/cas9 Technology” (2020-01 to 2022-12, ¥30,000, completed, Principal Investigator).
5. Jiangxi Provincial Department of Education, Science and Technology Research Project - “Histological Study on the Development of Honeybee from Egg to Larva” (2016-01 to 2017-12, ¥30,000, completed, Principal Investigator).
6. National Natural Science Foundation of China, 32172790 - “Multi-omics Analysis of Epigenetic Mechanisms in Honeybee Caste Differentiation” (2022-01-01 to 2025-12-31, ¥580,000, ongoing, Participant).
7. National Natural Science Foundation of China, 31960688 - “Analysis of Autophagy and Molecular Mechanisms in the Spleen of Weaned Piglets Induced by LPS” (2020-01-01 to 2023-12-31, ¥380,000, completed, Participant).
Representative Publications:
1. Xiaofen Hu; Bo Zhang; Chunhua Liao; Zhijiang Zeng. High-efficiency CRISPR/Cas9-mediated Gene Editing in Honeybee (Apis mellifera) Embryos. G3: Genes, Genomes, Genetics, 2019, 9(5): 1759-1766 (First Author).
2. Xiaofen Hu; Li Ke; Zhijiang Zeng. Histomorphological Study on Embryogenesis of the Honeybee Apis cerana. Journal of Asia-Pacific Entomology, 2019, 22(3): 860-867 (First Author).
3. Xiaofen Hu; Li Ke; Zilong Wang; Zhijiang Zeng. Dynamic Transcriptome Landscape of Asian Domestic Honeybee (Apis cerana) Embryonic Development Revealed by High-quality RNA Sequencing. BMC Developmental Biology, 2018, 18(1): 11-11 (First Author).
4. Xiaofen Hu; Fei Wang; Shanshan Yang; Xu Yuan; Tingyu Yang; Yunxiao Zhou; Yong Li. Rabbit Microbiota Across the Whole Body Revealed by 16S rRNA Gene Amplicon Sequencing. BMC Microbiology, 2021, 21(21): 312-312 (First Author).
5. Fuping Cheng; Xiaofen Hu Xiaofen; Luxia Pan; Zhixian Gong; Kaixin Qin; Zhen Li; Zilong Wang. Transcriptome Changes of Apis mellifera Female Embryos with fem Gene Knockout by CRISPR/Cas9. International Journal of Biological Macromolecules, 2022, 229: 260-267.
6. Xiaofen Hu; Li Ke; Zhijiang Zeng. Comparison of Three Methods for Preparing Honeybee Egg Tissue Sections. Journal of Jiangxi Agricultural University, 2016, 38(4): 729-733.
Patents:
1. Xiaofen Hu; Zhijiang Zeng; Zilong Wang; Weiyu Yan. Honeybee Gene Editing Method Based on CRISPR/Cas9. 2020-08-07, China, ZL201811635230.X.
2. Zilong Wang; Fuping Cheng; Luxia Pan; Xiaofen Hu; Zhijiang Zeng; Shuangyan Zheng. A Honeybee Egg Cultivation Box. 2021-07-20, China, ZL202022664234.X.
