Personal Information
Guanhong Li, born on October 29, 1974.Ph.D., Professor of Nutritional Immunology.
Mobile phone: +86-13979165229,E-mail:liguanhong@jxau.edu.cn.
Education Background:
Sep.2001~Mar.2005 Ph.D., School of Food Science and Technology, Jiangnan University.
Sep.1997~Jun.2000 M.S., College of Animal Science and Technology, Jiangxi Agricultural University, China.
Sep.1993~Jun.1997 B.S., College of Animal Science and Technology, Jiangxi Agricultural University, China.
Work Experience:
Jun.2015~Present Professor, Jiangxi Province Key Laboratory of Animal Nutrition/College of Animal Science and Technology, Jiangxi Agricultural University, China.
Nov.2014~May.2015 Academic visitor, Research group of Associate Prof. Lijuan Yuan (Associate Prof. ofVirology and Immunology),Virginia-Maryland College of Veterinary Medicine,Virginia Polytechnic Institute and State University (Virginia Tech), USA.
Nov.2012~Oct.2014Professor, Jiangxi Province Key Laboratory of Animal Nutrition/College of Animal Science and Technology, Jiangxi Agricultural University, China.
Oct.2011~Oct.2012 Academic visitor, Research group of Prof. Philip Calder (Professor of Nutritional Immunology), Faculty of Medicine, University of Southampton, UK.
Sep.2006~Sep.2011 Associate Professor, College of Animal Science and Technology, Jiangxi Agricultural University, China.
Sep.2005~Aug.2006 Visiting scientist, Research group of Prof. Yoshinori Mine, Department of Food Science, University of Guelph, Canada.
Aug.2000~Sep.2001 Lectuer, College of Animal Science and Technology, Jiangxi Agricultural University.
Affiliations and Partnerships：
World’s Poultry Science Association Member
International Endotoxin & Innate Immunity Society Member
Chinese Association of Animal Science and Veterinary Medicine Senior Member
Chinese Society for Immunology Senior Member
Chinese Association for Laboratory Animal Science Member
Scientific Reports Editorial Board Member
World Chinese Journal of Digestology Editorial Board Member
Acta Agriculturae Universitis Jiangxiensis Editorial Board Member
Research Interests
Intestinal mucosal immunity, and nutritionalregulation ofimmunefunction,determining how nutrients regulate immune function and the microbiome.Animal stress and nutritional regulation.The bacterial (probiotics)/epithelial interaction in the innate immunity in the intestinal epithelium,characterizing host mechanisms and signaling pathways that are important for the regulation of immune responses in the intestinal tract. Host defense peptides in innate and adaptive immunity.
Current Research Project
Exploring the underlying mechanisms by which enviromental stress factors induce intestinal barrier injury in broier chickens
The gastrointestinal tract is the target organ influenced by stress response, and it is extremely vulnerable to being influenced by various stress factors inculding heat and cold stresses, oxidative stress, immunological stress,high stocking density, resulting in intestinal mucosal damage. However, the underlying molecular mechanism by whichenviromentalstress damages the intestinal barrier function is still unclear. Our goal is to demonstrate the underlying mechanism by which the stressfactorsinducegastrointestinal damage,and to clarify the molecular mechanism underlying the anti- stress effects of specific nutrients/plant extracts/probiotics, which would contribute to enriching the heat stress theory and finding new potential biomarker for evaluatingenviromental stress-induced injury in broilers.
The current research projects are funded by the National Natural Science Foundation of China andJiangxi Provincial Natural Science Foundation.
Selected Publications
Publications in Peer-Reviewed International Journals:
1. Jingxin Ouyang, Chao Zhang, Chenxi Deng, Ai Wen, Hua Zhou, Jinming You,Guanhong Li*.Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers.Poultry Science, 2024, 103(11):104202.
2. Haoneng Guo, Shuangshuang Xiao, Wenfang Lou, Rifat Ullah Khan, Juanjuan Wu, Bo Huang,Sifa Dai*, Guanhong Li*.Dietarysupplementation ofglutamineimprovesmetabolicfunctions in 1-14daysoldbroilersundercoldstress. Pakistan Journal of Zoology,2024,56(3):1433-1438.
3. Chenxi Deng,Jun Zheng,Hua Zhou, Jinming You, Guanhong Li*.Dietary glycine supplementation prevents heat stress-induced impairment of antioxidant status and intestinal barrier function in broilers.Poultry Science, 2023, 102(3):102408.
4. Hua Zhou, Xuan Shi, Yingmei Yu, Lei Yang, Jingxin OuYang, Yinhao Bian, Yichun Liu, andGuanhong Li*.Puerarin Alleviates Oxidized Oil-Induced Oxidative Injury and Inflammation via Inhibition of the Nrf2/Keap1 and HMGB1/TLR4/MAPK Signaling Pathways: An Investigation in a Chicken Model.Molecular Nutrition & Food Research, 2023, 67(23): e2200663.
5. Hua Zhou, Lei Yang, Tiande Zou, Qiufen Li, Mingren Qu, Jingming You,Guanhong Li*. Regulation of poultry lipid metabolism by dietary fibre: a review.World's Poultry Science Journal, 79(3): 485-496.
6. Qiufen Li, Jingxin Ouyang, Chenxi Deng, Hua Zhou, Jinming You, Guanhong Li*.Effects of dietary tryptophan supplementation on rectal temperature, humoral immunity, and cecal microflora composition of heat-stressed broilers.Frontiers in Veterinary Science, 2023,10:1247260.
7. Jingxin Ouyang,Qiufen Li,Hua Zhou,Guiyao Li,Yajing Wu,Lei Yang, Guanhong Li*.Tryptophan alleviates chronic heat stress–induced impairment of antioxidant capacities, inflammatory response, and mitochondrial function in broilers.Tropical Animal Health and Production,2023,55(6): 425.
8. Ouyang J, Zhou H, Li Q, Zheng J, Chen C, Guo S, You J,Li G*.Tryptophanalleviatesacuteheat stress-inducedimpairment of antioxidantstatus andmitochondrial function inbroilers. Frontiers in Veterinary Science, 2022,9: 863156.
9. Qiufen Li, Hua Zhou, Jingxin Ouyang, Shuaipeng Guo, Jun Zheng,Guanhong Li*.Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress.Tropical Animal Health and Production, 2022, 54: 164.
10. Li Q, Ouyang J, Zhou H, You J,Li G*. Effect of probiotic supplementation on expression of tight junction proteins and innate immunity-associated genes and microbiota composition ofbroilers subjected to cyclic heat stress.Animal science journal, 2022, 93, e13719. https://doi.org/10.1111/asj.13719
11. Huang J, Li J, Li Q, Li L, Zhu N, Xiong X,Li G*.Peptidoglycan derived fromLactobacillus rhamnosus up-regulates the expression of chicken β-defensin 9 without triggering inflammatory response. Innate Immunity,2020, 26(8): 733-745.
12. Li Q, Wan G, Peng C, Xu L, Yu Y, Li L,Li G*.Effect of probioticsupplementationon growth performance, intestinal morphology, barrier integrity, and inflammatory response in broilers subjected to cyclic heat stress.Animal Science Journal, 2020,91(1): e13433.
13. Jia YJ, Si W, Hong ZM, Qu MR, Zhu NH, Liu SG,Li GH*.Toll-like receptor 2-mediated induction of avian β-defensin 9 byLactobacillus rhamnosus and its cellular components in chicken intestinal epithelial cells. Food and Agricultural Immunology,2019,30(1): 398-417.
14. Long G-L, Hao W-X, Bao L-F, Li J-H, Zhang Y,Li GH*.Effects ofdietary inclusion levels of palm oil on growth performance, antioxidative status andserumcytokines of broilerchickens.Journal of Animal Physiology and Animal Nutrition, 2019, 103(4).
15. Li GH*, Hong ZM, Jia YJ, You JM, Zhang JH, Liu BS.Probiotic Lactobacilli stimulate avian beta-defensin 9 expression in cultured chicken small intestinal epithelial cells.Proceedings of the Nutrition Society, 2012, 71 (OCE3):E239.
16. Li GH, Ling BM, Qu MR, et al.Effects of several oligosaccharides on ruminal fermentation: anin vitro experiment.Revue de Medecine Veterinaire,2011, 162: 192-197.
17. Li GH,Mine Y, Hincke MT, Nys Y.Isolation and characterization of antimicrobial proteins and peptide from chicken liver.Journal of Peptide Science, 2007, 13: 368-378.
18. Guan-Hong Li, Ming-Ren Qu, Nian-Hua Zhu, Xiang-Hua Yan. Determination of amino acid requirements and optimum dietary amino acid pattern for Taihe silky fowls in early stage.Asian-Australasian Journal of Animal Science, 2003, 16: 1782-1788.
