Name: Zhuang Yu

Date of Birth: February 1988

Gender: Male

Ethnicity: Han

Place of Birth: Ganzhou, Jiangxi, China

Degree: Ph.D., Postdoctoral Researcher (2016-2019, Mentor: Yulong Yin)

Current Position: Lecturer, Twelfth Batch “Future Star” of Jiangxi Agricultural University

Professional Associations:

· Member of the Council of the Veterinary Internal Medicine and Clinical Diagnostics Committee and Imaging Committee, Chinese Association of Animal Science and Veterinary Medicine

· Executive Member and Deputy Secretary-General of the Traditional Chinese Veterinary Medicine Research Association in East China

· Licensed National Veterinarian

· Key Member of the Poultry Industry Quality Safety and Environmental Control Post and Disease Prevention and Control Post of the Cattle and Sheep Industry System in Jiangxi Province

· Expert Consultant for Various Agricultural Projects: Meat Pigeon Industry Technology Academy in Suichuan County, Rabbit Industry Technology Academy in Shangli County, "Professor Tian" Service Group in Taihe County, and “Soviet Zone Revitalization” Expert Advisor in Dayu County

Current Work: Engaged in teaching and research at the College of Animal Science and Technology, Jiangxi Agricultural University, focusing on traditional Chinese veterinary medicine and veterinary clinical studies. Dr. Zhuang has solid clinical veterinary skills and specializes in identifying the functions of traditional Chinese veterinary medicine and natural active ingredients, as well as research in animal nutrition, metabolism, and toxicity-related diseases. He has led or participated in over 10 national and provincial-level research projects and has published more than 60 academic papers, with over 20 SCI papers as the first author. Dr. Zhuang holds two national patents.

Education

· Ph.D. (2013-2016), College of Animal Science and Technology, Jiangxi Agricultural University, Advisor: Guoliang Hu

· Master’s (2010-2013), College of Animal Science and Technology, Jiangxi Agricultural University, Advisor: Guoliang Hu

· Bachelor’s (2006-2010), College of Animal Science and Technology, Jiangxi Agricultural University

Work Experience

· Lecturer (July 2019–Present), College of Animal Science and Technology, Jiangxi Agricultural University

· Postdoctoral Researcher (July 2016–June 2019), College of Life Sciences, Hunan Normal University, Advisor: Yulong Yin

Research Projects and Talent Plans

[1] National Natural Science Foundation: "The Role of LncRNA-1092.1/miR-15b-5p/PLIN2 Axis in Lipophagy Dysfunction in Laying Hens with Fatty Liver Hemorrhagic Syndrome" (32460910), 320,000 RMB, Principal Investigator

[2] General Project of the National Natural Science Foundation: "Molecular Mechanism of Natural Immune Signal Regulating Intestinal Epithelial Cell Shedding" (31871469), 250,000 RMB, Co-Investigator, Second Author, Project Completed

[3] General Project of the National Natural Science Foundation: "MiR-15b-5p Targeting SIRT3 to Regulate Mitochondrial Energy Metabolism in Fatty Liver Hemorrhagic Syndrome in Laying Hens" (32373090), 500,000 RMB, Co-Investigator, Second Author, Ongoing

[4] Regional Project of the National Natural Science Foundation: "The Role and Mechanism of Gut Microbiota and Short-Chain Fatty Acids in Insulin Resistance of FLHS Hens" (32060819), 350,000 RMB, Co-Investigator, Second Author, Ongoing

[5] Regional Project of the National Natural Science Foundation: "Insulin/PI3K/AKT Pathway in the Mechanism of High-Energy, Low-Protein Diet-Induced Fatty Liver Hemorrhagic Syndrome in Laying Hens" (31560715), 400,000 RMB, Co-Investigator, Ongoing

[6] Jiangxi Provincial Natural Science Foundation Project: "Mechanism of Vomitoxin-Induced Pig Intestinal Damage via TRPML1-Mediated Macrophage Autophagy and Polarization" (20224BAB215053), 100,000 RMB, Principal Investigator

[7] Industry Project: "Protective Mechanism of Baicalin against E. coli-Induced Intestinal Inflammation in Chicks Based on Macrophage Polarization" (2021.01~2022.01), 550,000 RMB, Principal Investigator, Completed

[8] Jiangxi Provincial Department of Education Science and Technology Plan Project: "SESN2-Mediated Autophagy in Heat Stress-Induced Intestinal Damage in Pigs" (GJJ190221), 30,000 RMB, Principal Investigator

[9] China Postdoctoral Science Foundation: "SESN2-Mediated Mitochondrial Autophagy in Repair Mechanisms of Pig Intestinal Epithelial Cell Damage" (2017M612562), 50,000 RMB, Principal Investigator

[10] Jiangxi Agricultural University Teaching Reform Project: "PBL Teaching Method in the Curriculum Reform of Traditional Chinese Veterinary Medicine" (2020.1-2022.12), 3,000 RMB, Principal Investigator

[11] Jiangxi Provincial Graduate Innovation Project: "Relationship and Mechanism of apoA-I/IV/V Gene Polymorphism with Lipid Metabolism in FLHS Susceptible Models in Chickens" (YC2014-BO36), 5,000 RMB, Principal Investigator

Representative Research Achievements (Past Five Years)

[1] Xinyi, Cheng., Yang, Hu., Jun, Kuang., Xiaoquan, Guo., Huabin, Cao., Huansheng, Wu., Guoliang, Hu., Yu, Zhuang*.(2024). Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics. Poult Sci, 103(8), 0. doi:10.1016/j.psj.2024.103968

[2] Ding Jiayi., Liu Jiuyue., Chen Jinyan., Cheng Xinyi., Cao Huabin., Guo Xiaoquan., Hu Guoliang.,Zhuang Yu*.(2024). Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway. Poult Sci, 103(4), 103482.

[3] Cheng Xinyi., Hu Yang., Yu Xiaoqing., Chen Jinyan., Guo Xiaoquan., Cao Huabin., Hu Guoliang.,Zhuang Yu*.(2024). Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway. Antioxidants (Basel), 13(2), 13020140.

[4] Wang Chang., Yang Yitian., Chen Jinyan., Dai Xueyan., Xing Chenghong., Zhang Caiying., Cao Huabin., Guo Xiaoquan., Hu Guoliang.,Zhuang Yu*.(2023). Berberine Protects against High-Energy and Low-Protein Diet-Induced Hepatic Steatosis: Modulation of Gut Microbiota and Bile Acid Metabolism in Laying Hens. Int J Mol Sci, 24(24), 242417304.

[5] Cheng Xinyi., Chen Jinyan., Guo Xiaoquan., Cao Huabin., Zhang Caiying., Hu Guoliang.,Zhuang Yu*.(2024). Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice. Environ Pollut, 343(undefined), 123232.

[6] Wang Chang., Dai Xueyan., Xing Chenghong., Zhang Caiying., Cao Huabin., Guo Xiaoquan., Liu Ping., Yang Fan.,Zhuang Yu.*, Hu Guoliang.*(2023). Hexavalent-Chromium-Induced Disruption of Mitochondrial Dynamics and Apoptosis in the Liver via the AMPK-PGC-1αPathway in Ducks. Int J Mol Sci, 24(24), 242417241.

[7] Liang Jiahua., Chen Jinyan., Yang Lingling., Wu Dan., Xiong Lijuan., Guo Xiaoquan., Cao Huabin., Zhang Caiying., Hu Guoliang.,Zhuang Yu*.(2024). Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway. Biomed Pharmacother, 171(undefined), 116205.

[8] Cheng Xinyi., Liang Jiahua., Wu Dan., Guo Xiaoquan., Cao Huabin., Zhang Caiying., Liu Ping., Hu Ruiming., Hu Guoliang.,Zhuang Yu*.(2023). Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux. Ecotoxicol Environ Saf, 257(undefined), 114942.

[9] Liang Jiahua., Zhou Ying., Cheng Xinyi., Chen Jiaqi., Cao Huabin., Guo Xiaoquan., Zhang Caiying.,Zhuang Yu.*, Hu Guoliang*.(2023). Baicalin Attenuates H2O2-Induced Oxidative Stress by Regulating the AMPK/Nrf2 Signaling Pathway in IPEC-J2 Cells. Int JMol Sci, 24(11), 24119435.

[10]Yu Zhuang, Huijun Huang, Shuang Liu, Feng Liu, Qiang Tu，Yulong Yin, Shanping He*. Resveratrol Improves Growth Performance, Intestinal Morphology, and Microbiota Composition and Metabolism in Mice[J]. Front Microbiol, 2021, 12: 726878.

[11] Cao Zhanyou., Xing Chenghong., Cheng Xinyi., Luo Junrong., Hu Ruiming., Cao Huabin., Guo Xiaoquan., Yang Fan.,Zhuang Yu.*, Hu Guoliang*.(2022). Luteolin Attenuates APEC-Induced Oxidative Stress and Inflammation via Inhibiting the HMGB1/TLR4/NF-κB Signal Axis in the Ileum of Chicks. Animals (Basel), 13(1), 13010083.

[12] Cheng Xinyi, Liu Jiuyue, Zhu Yibo, Guo Xiaoquan, Liu Ping, Zhang Caiying, Cao Huabin, Xing Chenghong,Zhuang Yu*, Hu Guoliang*. Molecular cloning, characterization, and expression analysis of TIPE1 in chicken (Gallus gallus): Its applications in fatty liver hemorrhagic syndrome. Int J Biol Macromol, 2022, 207, 905-916.

[13]Yu Zhuang, Huirong Wu, Xiangxiang Wang, Jieyu He, Shanping He, Yulong Yin*. Resveratrol attenuates oxidative stress-induced intestinal barrier injury through PI3K/Akt-mediated Nrf2 signaling pathway. Oxid Med Cell Longev, 2019, 7591840.

[14]Zhuang Yu., Xing Chenghong., Cao Huabin., Zhang Caiying., Luo Junrong., Guo Xiaoquan., Hu Guoliang.(2019). Insulin resistance and metabonomics analysis of fatty liver haemorrhagic syndrome in laying hens induced by a high-energy low-protein diet. SciRep, 9(1), 10141.

Patents and Copyrights

[1] Zhuang, Y.; Liu, Jianguo. Portable Veterinary Toolbox, March 23, 2020, China, ZL202020371236.7 (Patent)

[2] Zhuang, Y.; Chen, Lin. Disinfection Device for Livestock Reproduction Instruments, March 31, 2020, China, ZL202020447322.1 (Patent)

[3] Jiangxi Agricultural University; Zhuang, Y.; Hu, Guoliang; Guo, Xiaoquan; Zhang, Caiying; Cheng, Xinyi. Virtual Simulation Experiment System for Emergency Diagnosis and Treatment of Acute Organophosphorus Pesticide Poisoning in Livestock and Poultry Farms, 2021SR1543821 (Software Copyright)