Doctor of Veterinary Medicine, graduated from Nanjing Agricultural University, and has published more than 10 papers in Carbohydr Polym, International Journal of Biological Macromolecules, Food & Function, Phytomedicine and other journals. Main research areas: 1) Extraction, purification and structural analysis of herbal polysaccharides; 2) The immunomodulatory activity of Chinese traditional medicine polysaccharides, and its effect on the regulation of intestinal immune function and intestinal microflora structure; 3) Design, development and effect evaluation of traditional Chinese medicine polysaccharide as an oral vaccine adjuvant, and study on its protective immune response mechanism.

E-mail: cgf19920617@163.com;Add：Jiangxi Agricultural University;

Tel：18770054384;ORCID: https://orcid.org/0000-0001-9220-7399

Name：Cai Gaofeng Gender：Man Country：China

Birthplace：Zhuji City, Zhejiang Province Birthdate：1992.06

Age：32 Education：Doctor Professional title：Professor of theJiangxi Agricultural University

Education

2019 -2023College of Veterinary Medicine, Nanjing Agricultural University，Doctor of Veterinary Medicine

2014 - 2017College of Animal Science and Technology, Jiangxi Agricultural University, Master of Preventive Veterinary Medicine

2010 - 2014College of Animal Science and Technology, Jiangxi Agricultural University, Bachelor of Veterinary Medicine

Work experience

2023 -presentCollege of Animal Science and Technology, Jiangxi Agricultural University, engaged in the traditional Chinese veterinary medicine

Projects the applicant has undertaken either as Principal Investigator orparticipant in the last 5 years

1.Jiangxi Provincial Natural Science Foundation,Youth Science Fund project, 20242BAB20314, Study on improving mucosal immunity effect of PEDV oral vaccine by Pueraria polysaccharide-dendritic fibrous nanostructured silica particles and its mechanism of action, 2024-6-1/2027-5-31,100000 yuan, Under research,Principal Investigator.

2.National Natural Science Foundation,Youth Science Fund project,32402938,The research on the mechanism of regulation of Pueraria lobata polysaccharides on the production of lysozyme by Paneth cells in intestinal to prevent ETEC infection in piglets，2025-01-01/2027-12-31,300000 yuan,Under research, Principal Investigator.

3.National Natural Science Foundation,Research Grants,32072905,Study on the adjuvant activity and mechanism of Pickering emulsion of polysaccharide from Chinese medicine,2021-01-01/2024-12-31,580000 yuan, Under research,Participant.

4.National Natural Science Foundation,Regional Science Fund project,32460850,The interaction between rumen microorganism and host mediates the mechanism of puerarin promoting intramuscular fat deposition in meat sheep,2025-01-01/2028-12-31,320000 yuan, Under research,Participant.

5. Jiangxi Agricultural University PhD start-up funding, 9232310350,300000 yuan, Under research,Principal Investigator.

Patent for invention

Wang Deyun, LI Youying, WU Zhiyong, ZHU Shaowu,CAI Gaofeng, LAN LAN, Pan Yao. Patent No. : CN202110613153.3,A traditional Chinese medicine composition and its preparation method and application in the prevention or anti-diarrhea, Invention Patent, Grant time: February 11, 2022, China.

Representative publications

[1] Cai, G., Wu, C., Zhu, T., Peng, S., Xu, S., Hu, Y., Liu,Z., Yang, Y., Wang,D. Structure of a Pueraria root polysaccharide and its immunoregulatory activity on T and B lymphocytes, macrophages, and immunosuppressive mice[J]. International Journal of Biological Macromolecules,2023, 230:123386.

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[2] Cai, G., Wu, C., Mao, N., Song, Z., Yu, L., Zhu, T., Peng, S., Yang, Y., Liu, Z., & Wang, D. Isolation, purification and characterization of Pueraria lobata polysaccharide and its effects on intestinal function in cyclophosphamide-treated mice[J]. InternationalJournal ofBiologicalMacromolecules, 2022, 218: 356-367.

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[3] Cai, G., Yang, Y., Gu, P., Li, K., Adelijiang, W., Zhu, T., Liu, Z., & Wang, D. The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides[J]. Phytomedicine,2022, 103: 154232.

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[4]Cai, G., Wu, Y., Wusiman, A., Gu, P., Mao, N., Xu, S., Zhu, T., Feng, Z., Liu, Z., & Wang, D. Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice[J]. Food & function,2021,12(15):6863–6877.

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[5] Cai, G., Wusiman, A., Gu, P., Mao, N., Xu, S., Zhu, T., He, J., Liu, Z., & Wang, D. Supplementation of Alhagi honey polysaccharides contributes to the improvement of the intestinal immunity regulating the structure of intestinal flora in mice[J]. Food & function,2021, 12(20):9693–9707.

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[6]Cai, G., Mao, N., Gu, P., Zhu, T., He, J., Peng, S.,Yang, Y., Liu, Z., Hu, Y., Wang, D. Effects of Alhagi Honey Polysaccharides as Feed Supplement on Intestine Function and Microbiome, Immune Function, and Growth Performance in Chicken[J]. International Journal Of Molecular Sciences, 2022, 23(22): 14332.

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[7] Cai Gaofeng, Mao Ningning, Zhu Tianyu, He Jin, Zhu Shaowu, Xue Rui, Lei Shangshang, Liu Zhenguang, Hu Yuanliang, Wang Deyun. The regulatory effect of prickly polysaccharides on the immune function of chickens after immunization with Newcastle disease vaccine[J]. Livestock and Veterinary Medicine, 2023, 55 (02): 129-134.

[8] Wusiman, A., He, J.,Cai, G., Zhu, T., Bo, R., Liu, Z., Hu, Y., & Wang, D. Alhagi honey polysaccharides encapsulated into PLGA nanoparticle-based pickering emulsion as a novel adjuvant to induce strong and long-lasting immune responses[J]. International Journal of Biological Macromolecules,2022, 202:130–140.

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[9] Gu, P.,Cai, G., Yang, Y., Hu, Y., Liu, J., & Wang, D. Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms[J]. InternationalJournal ofBiologicalMacromolecules,2022, 207: 559–569.

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[10] Gu, P., Zhang, Y.,Cai, G., Liu, Z., Hu, Y., Liu, J., & Wang, D. Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses[J]. Molecular pharmaceutics,2021, 18(6): 2274–2284.

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[11] Gu, P., Wusiman, A., Zhang, Y.,Cai, G., Xu, S., Zhu, S., Liu, Z., Hu, Y., Liu, J., & Wang, D. Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant for H9N2 vaccine to improve immune responses in chickens compared to Alum and oil-based adjuvants[J]. Veterinary microbiology,2020, 251: 108894.

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[12] Shuwen Xu; Zhiyong Wu;Gaofeng Cai; Yue Zhang; Song Peng; Lina Jiao; Zhenguang Liu; Yang Yang; Deyun Wang. Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice[J]. Vaccine. 2023, 41(10): 1684-1693.

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[13] Zhang, Yue; Zhu, Tianyu; Xu, Shuwen; Gu, Pengfei;Cai, Gaofeng; Peng, Song; Liu, Zhenguang; Yang, Yang; Hu, Yuanliang; Liu, Jiaguo; Wang, Deyun. Cationic nanoparticles-stabilized vaccine delivery system for the H9N2 vaccine to promote the immune response in chickens.Molecular Pharmaceutics[J].2023, 20(3): 1613-1623.

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[14] Yang Y, Lv L, Shi S,Cai G, Yu L, Xu S, Zhu T, Su X, Mao N, Zhang Y, Peng S, He J, Liu Z, Wang D. Polysaccharide from walnut green husk alleviates liver inflammation and gluconeogenesis dysfunction by altering gut microbiota in ochratoxin A-induced mice.Carbohydr Polym. 2023, 322:121362.

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[15] He J, Zhu T, Mao N,Cai G, Gu P, Song Z, Lu X, Yang Y, Wang D. Cistanche deserticola polysaccharide-functionalized dendritic fibrous nano-silica as oral vaccine adjuvant delivery enhancing both the mucosal and systemic immunity. Int J Biol Macromol. 2024, 262(Pt 2):129982.

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