Huang Jianzhen, a native of XinGan County, Jiangxi Province, is a doctor, professor, and doctoral supervisor.She is the leader of the Basic Veterinary Medicine discipline, the director of the Nanchang City Animal Physiology and Biochemistry Key Laboratory, and the leader of the “Animal Physiology, Biochemistry, and Metabolic Integration Biology” Youth Innovation Team at Jiangxi Agricultural University.She has been a visiting scholar at Iowa State University, USA, and Tsinghua University.She is also a standing member/deputy secretary general of the Animal Physiology and Biochemistry Branch of the Chinese Society of Animal Science and Veterinary Medicine, vice chairman of the Jiangxi Provincial Society of Biochemistry and Molecular Biology, and a senior member of the Chinese Society of Animal Science and Veterinary Medicine.

Her main teaching areas include “Animal Biochemistry,” “Modern Animal Biochemistry,” “Molecular Biology,” and “Frontier of Epigenetics,” with an “Excellent Level 1” teaching quality.Hermain research direction focuses on animal lipid metabolic disorders, animal energy metabolism, and epigenetic regulation mechanisms of reproductive development.She has led three National Natural Science Foundation projects, one sub-project of a national key research and development project, and numerous provincial and ministerial projects.She has also been a core member of several national key research and development projects and other national natural science foundation projects.

She has published over 20 SCI papers in journals such as JASB, Poultry Science, Animal Nutrition, BMC genomics, EJCB, Steroids, and Lipids.She has also published over 40 papers in CSCD Chinese core journals such as Acta Veterinaria et Zootechnica Sinica, Chinese Journal of Veterinary Medicine, Acta Nutrimenta Animal, Journal of Biological Engineering, and Journal of Jiangxi Agricultural University.She has also obtained three national utility model patents.

Education

2016/03 - 2017/03: Molecular Genetics, Iowa State University (Visiting Scholar), collaborating mentor: Professor Christopher K. Tuggle

2014/06 - 2015/06:Lipid Metabolism Biology, School of Life Sciences, Tsinghua University (Domestic Visiting Scholar), collaborating mentor: Professor Li Peng (Academician)

2005/09 - 2008/06: Doctor of Philosophy in Basic Veterinary Medicine (Animal Biochemistry), Nanjing Agricultural University, Advisor: Professor Zou Sixiang

2002/09 - 2005/06: Master of Science in Basic Veterinary Medicine (Animal Biochemistry), Jiangxi Agricultural University, Advisor: Professor Shen Qiugu

1995/09 - 1999/06: Bachelor of Science in Veterinary Medicine, Jiangxi Agricultural University

Research and academic work experience

2018/11 - Present: Professor, College of Animal Science and Technology, Jiangxi Agricultural University

2016/03 - 2017/03: Visiting Scholar, Iowa State University, collaborating mentor: Professor Christopher K. Tuggle

2011/10 - 2018/11: Associate Professor, College of Animal Science and Technology, Jiangxi Agricultural University

2014/06 - 2015/06: Visiting Scholar, School of Life Sciences, Tsinghua University (Domestic Visiting Scholar), collaborating mentor: Professor Li Peng (Academician)

2005/09 - 2011/09:Lecturer, College of Animal Science and Technology, Jiangxi Agricultural University

2003/03 - 2004/05:Research Assistant, Institute of Animal Husbandry and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Focus: Gene Engineering, Co-Advisor: Researcher Li Zhen

1999/07 - 2005/08: Assistant Lecturer, College of Animal Science and Technology, Jiangxi Agricultural University

Representative Research Achievements

（1）Meng Ru^#, Haiping Liang, Jiming Ruan, RAMLAT ALI HAJI, Yong Cui, Chao Yin, Qing Wei,Jianzhen Huang^*. Chicken ovarian follicular atresia: interaction network at organic, cellular, and molecular levels[J]. Poultry Science, 2024,Aug;103(8):103893

（2）Yong Cui^#, Meng Ru, Yujie Wang, Linjian Weng, Ramlat Ali Haji, Haiping Liang, Qingjie Zeng, Qing Wei, Xianhua Xie, Chao Yin,Jianzhen Huang^*. Epigenetic regulation of H3K27me3 in laying hens with fatty liver hemorrhagic syndrome induced by high‑energy and low-protein diets[J]. BMC Genomics. 2024; 16;25(1):374

（3）Jinhu Ma^#, Dandan You, Shuwen Chen, Nana Fang, Xinrui Yi, Yi Wang, Xuejin Lu, Xinyu Li, Meizi Zhu, Min Xue, Yunshu Tang, Xiaohui Wei,Jianzhen Huang^*, Yaling Zhu^*. Epigenetic association study uncovered H3K27 acetylation enhancers and dysregulated genes in high-fat-diet-induced nonalcoholic fatty liver disease in rats[J]. Epigenomics. 2023;14(23):1523-1540

（4）Tao Jiang^# , Ziqi Ling^# , Zhimin Zhou, Xiaoyun Chen, Liqing Chen, Sha Liu, Yingchun Sun, Jiawen Yang, Bin Yang^*,Jianzhen Huang^* and Lusheng Huang. Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs [J]. Journal of Animal Science and Biotechnology. 2022;13:112

（5）Zhu Y L^#, Zeng Q J, Li F, Fang H S, Zhou Z M, Jiang T, Yin C, Wei Q, Wang Y J, Ruan J M* and Huang J Z^*. Dysregulated H3K27 acetylation is implicated in fatty liver hemorrhagic syndrome in chickens[J]. Frontier in Genetics. 2020; 11: 574167.

（6）Zhu Yaling^#; Mao Huirong^#; Peng Gang; Zeng Qingjie; Ruan Jiming^* and Huang Jianzhen^*. Effect of JAK-STAT pathway in regulation of fatty liver hemorrhagic syndrome in chickens[J]. Anim Biosci. 2021 Jan;34(1):143-153.

（7）Peng Gang^#; Huang Enfu^#; Ruan Jiming; Huang Liumei; Liang Haiping; Wei Qing; Xie Xianhua; Zeng Qingjie^* and Huang Jianzhen^*. Effects of a high energy and low protein diet on hepatic and plasma characteristics and Cidea and Cidec mRNA expression in liver and adipose tissue of laying hens with fatty liver hemorrhagic syndrome[J]. Animal Science Journal, 2019.2; 90(2):247-254.

（8）Luo Chengting^#; Lv Na; Chang Zai; Qu Qiannuo; Huang Jianzhen^*. Adipose angiotensin II type 1 receptor-associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning[J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2017.9, 96(6): 567~578.

（9）Huang Jianzhen^#; Huang Liumei^#; Zeng Qingjie; Huang Enfu; Liang Haiping; Wei Qing; Xie Xianhua; Ruan Jiming^*. Distribution and quantitative analysis of CIDEa and CIDEc in broiler chickens: accounting for differential fat deposition between strains[J]. British Poultry Science, 2017.12.20, 60(1).

（10）Yang Fei^#; Ruan Jiming^#; Wang Tiancheng; Luo Junrong; Cao Huabin; Song Yalu; Huang Jianzhen^*; Hu Guoliang^*. Improving effect of dietary soybean phospholipids supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome in laying hens[J]. Animal Science Journal, 2017.11, 8 8(11): 1860~1869.

（11）Song Yalu^#; Ruan Jiming^#; Luo Junrong; Wang Tiancheng; Yang Fei; Cao Huabin; Huang Jianzhen^*; Hu Guoliang^*. IMMUNOLOGY, HEALTH, AND DISEASE Abnormal histopathology, fat percent and hepatic apolipoprotein A I and apolipoprotein B-100 mRNA expression in fatty liver hemorrhagic syndrome and their improvement by soybean lecithin[J]. POULTRY SCIENCE, 2017.10, 96(10): 3559~3563.

（12）Huang Jianzhen^#; Ruan Jiming; Tang Xue; Zhang Wei; Ma Haitian^*; Zou Sixiang, Comparative proteomics and phosphoproteomics analyses of DHEA-induced on hepatic lipid metabolism in broiler chickens[J]. STEROIDS, 2011. 12.20, 76(14): 1566~1574.

（13）Huang Jianzhen^#; Ma Haitian; Yang Liming.; Zou Sixiang^*. Developmental changes of protein profiles in the embryonic sanhuang chicken liver[J]. JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE, 2007.11, 54(9): 464~469.

（14）Huang Jianzhen^#; Tang Xue; Ruan Jiming; Ma Haitian^*; Zou Sixiang. Use of Comparative Proteomics to Identify Key Proteins Related to Hepatic Lipid Metabolism in Broiler Chickens: Evidence Accounting for Differential Fat Deposition Between Strains[J]. LIPIDS, 2010.1, 45(1): 81~89.

（15）Zhang F^#, Hu K^#, Huang, J, Tan, Z, Ruan, J*. Effects of two kinds of fishery drugs on the expressions of GAD and GABA-T mRNA in crucian carp (Carassius auratus gibelio) [J]. Fish Physiol Biochem. 2020, 46:1965–1973.

（16）Chen, Juan^#; Huang, Jianzhen; Deng, Jun; Ma, Haitian^*; Zou, Sixiang, Use of comparative proteomics to identify the effects of creatine pyruvate on lipid and protein metabolism in broiler chickens[J]. VETERINARY JOURNAL, 2012.8, 193(2 ): 514~521.

（17）Chen Suhua^#, Cao Minjie, Huang Jianzhen, Wu Guoping^*. Identification of a puromycin-sensitive aminopeptidase from zebrafish (Danio rerio). Comparative Biochemistry and Physiology Part B. 2011, 159(1):10-17.

（18）Beiki Hamid^#, Liu Haibo, Huang Jianzhen, Manchanda, Nonneman, Smith, Reecy and C. Tuggle Christopher^*. Improved annotation of the domestic pig genome through integration of Iso-Seq and RNA-seq data[J]. BMC Genomics. 2019 May 7;20(1):344.

（19）Huang Jianzhen^#, YU Ruisong, SHEN Qiugu, LI Xiangrui, LI Zhen^*. Study on renaturation of recombinant bovine interleukin-2 expressed in Escherichia coli[J]. Acta Agriculturae Shanghai, 2006 ,22 (4) : 27 - 32

Research Projects and Talent Programs

1. National Natural Science Foundation of China (NSFC) Regional Project: Epigenetic Regulation of Ovary Function and Egg Production in Laying Hens under Different Dietary Energy Levels Based on Hypothalamus-Pituitary-Ovary Axis (32360867), 2024/01-2027/12, ¥320,000 (USD 45,000), Ongoing, Project Manager.

2. National Key Research and Development Program (2030 Project) Sub-Project: Integrated Technologies for High Reproductive Breeding (2023ZD0404501), 2024/01-2025/12, ¥1,600,000 (USD 225,000), Ongoing, Project Manager.

3. NSFC Regional Project: Epigenetic Mechanisms of Fatty Liver Hemorrhagic Syndrome in Laying Hens Induced by High-Energy Low-Protein Diets (31960690), 2020/01-2023/12, ¥460,000 (USD 65,000), Completed, Project Manager.

4. National Key R&D Program: Precise Identification of Excellent Germplasm Resources in Major Mono-gastric Farm Animals and Aquatic Organisms - Exploration and Utilization of Agricultural Biological Germplasm Resources (2022/01-2026/12), ¥19,500,000 (USD 2,750,000), Ongoing, Major Contributor.

5. NSFC Regional Project: Liver Proteomic Study of Fatty Liver Hemorrhagic Syndrome in Laying Hens (31460648), 2015/01-2018/12, ¥480,000 (USD 68,000), Completed, Project Manager.

6. NSFC Youth Project: Role and Mechanisms of IRX3 in the Proliferation and Differentiation of Skeletal Muscle Satellite Cells in Pigs (31702201), 2018/01-2020/12, ¥250,000 (USD 35,000), Completed, Major Contributor.

7. NSFC Regional Project: The Relationship Between Xanthine Oxidase and Gout Induced by High Calcium Diets and Renal Newcastle Disease in Chickens (31260627), 2013/01-2016/12, ¥480,000 (USD 68,000), Completed, Major Contributor.