1. Introduction

Xie Shuang (born October 1994), female, Han ethnicity, from Xinyang, Henan, holds a Ph.D., is a lecturer, and is a specially appointed professor. She graduated in 2024 from Nanjing Agricultural University with a Doctor of Agriculture in Basic Veterinary Medicine. In July 2024, she joined Jiangxi Agricultural University and is currently a member of the Preventive Veterinary Medicine Teaching and Research Section at the College of Animal Science and Technology. Her main focus is on teaching and scientific research in preventive veterinary medicine, with a primary research direction on the interaction between intestinal microorganisms and the mucosal epithelium of livestock and poultry, as well as research related to intestinal mucosal immunity. She has published more than 10 representative papers in top journals such as "Journal of Hazardous Materials," "Free Radical Biology and Medicine," and "Journal of Agricultural and Food Chemistry." As a key contributor, she has been granted three national invention patents and has led and completed one Jiangsu Province Graduate Research Practice Innovation Project. She has also participated in one National Key R&D Program project, two National Natural Science Foundation projects, and one provincial project.

2. Mailing Address: No. 1101 Zhimin Avenue, National Economic and Technological Development Zone, Nanchang, Jiangxi Province, China, North Campus of Jiangxi Agricultural University, 2nd Floor, Room 214, North Building, College of Animal Science and Technology. Email:shuangxie1012@163.com.

3. Education Background:

（1) September 2020 - June 2024: Nanjing Agricultural University, Doctor of Agriculture in Basic Veterinary Medicine.

（2) September 2017 - June 2020: Nanjing Agricultural University, Master of Agriculture in Basic Veterinary Medicine.

（3) September 2013 - July 2017: Henan University of Animal Husbandry and Economy, Bachelor of Agriculture in Veterinary Medicine.

4. Work Experience:

· July 2024 - Present: Lecturer, College of Animal Science and Technology, Jiangxi Agricultural University.

5. Representative Research Papers

（1) SHUANG XIE, LAN JIANG, MINJUAN WANG, WENJING SUN, SIYONG YU, JERROLD R. TURNER, QINGHUA YU*. Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine [J]. Journal of Hazardous Material, 391 (2020) 122262.

（2) SHUANG XIE, RUI ZHANG, ZHAOYAN LI, CHUNRU LIU, WEIWEI XIANG, QIANQIAN LU, YANYU CHEN, QINGHUA YU*. Indispensable role of melatonin, a scavenger of reactive oxygen species (ROS), in the protective effect of Akkermansia muciniphila in cadmium induced intestinal mucosal damage [J]. Free Radical Biology and Medicine, 193 (2022) 447-458.

（3) SHUANG XIE, RUI ZHANG, ZHAOYAN LI, CHUNRU LIU, YANYU CHEN, QINGHUA YU*. Microplastics perturb colonic epithelial homeostasis associated with intestinal overproliferation, exacerbating the severity of colitis [J]. Environmental Research, 217 (2023) 114861.

（4) SHUANG XIE, SHIYI ZHAO, LAN JIANG, LINHAO LU, QIAN YANG, and QINGHUA YU*. Lactobacillus reuteri Stimulates Intestinal Epithelial Proliferation and Induces Differentiation into Goblet Cells in Young Chickens [J]. Journal of Agricultural and Food Chemistry, 2019, 67, 49, 13758-13766.

（5) SHUANG XIE, HANG ZHANG, RADEBE STOFFEL MATJEKE, JIAYI ZHAO, QINGHUA YU*. Bacillus coagulans protect against Salmonella enteritidis induced intestinal mucosal damage in young chickens by inducing the differentiation of goblet cells [J]. Poultry Science, 2022,101(3),101639.

（6) SHUANG XIE, YUCHEN LI, SHIYI ZHAO, YINGJU LV⁎, QINGHUA YU⁎. Salmonella infection induced intestinal crypt hyperplasia through Wnt/β-catenin pathway in chicken [J]. Research in Veterinary Science,2020,130,179-183.

（7) HAIQIN WU*, SHUANG XIE*, JINFENG MIAO*, YUCHEN LI, ZHIHUA WANG, MINJUAN WANG, QINGHUA YU*. Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa [J]. Gut Microbes, 2020,11(4):997-1014.

6. Research Projects

（1) Jiangxi Agricultural University Talent Introduction Startup Project, 300,000 RMB, Principal Investigator.

（2) Jiangsu Province Graduate Research and Practice Innovation Plan Project: Research on the Mechanism of Inhibition of PEDV Infection by Innovative Lactobacillus, 2021-2023, 15,000 RMB, Principal Investigator.

（3) National Natural Science Foundation of China: Research on the Mechanism of Enhancement of Intestinal Mucosal Barrier Defense against PEDV Infection by Lactobacillus reuteri D8, 2020-2023, 660,000 RMB, Participant.

（4) National Key R&D Program: Research on the Mechanism of Probiotics Regulating Porcine Intestinal Mucosal Barrier and Development of High-Throughput Screening and Production Technology, 2020-2022, 3,450,000 RMB, Participant.

7. Invention Patents and Honors

（1) Patent: Qinghua Yu, Shuang Xie, Shiyi Zhao, Yuchen Li, and Qian Yang, A strain of Lactobacillus reuteri 22 and its application, Patent No.: CN110540950B.

（2) Patent: Qinghua Yu, Junpeng Jia, Shuang Xie, Jia Yi Zhao, Minjuan Wang, A strain of Enterococcus faecalis YQH2 and its application, Patent No.: CN112795508B.

（3) Patent: Qinghua Yu, Linda Zhu, Jia Yi Zhao, Xiaoxi Lu, Linhao Lu, Minjuan Wang, Shuang Xie, Recombinant expressed Akkermansia muciniphila membrane protein Amuc_1100 and its application, Patent No.: CN110698547A.

（4) Honors and Awards: She has received the title of Outstanding Doctoral Graduate from Nanjing Agricultural University (2024), National Scholarship for Doctoral Students (2023), Outstanding Master's Thesis from Nanjing Agricultural University (2021), President's Scholarship from Nanjing Agricultural University (2020), "Warm Intestine" Scholarship (2020), First Prize for Outstanding Paper at Jiangsu Province Veterinary Medicine Graduate Forum (2019), and Outstanding Graduate of Henan Province (2017).