Personal Data

Name: Huansheng WuGender: Male

Day of birth: 1988.04Political status: Party Member of CPC

Career: Associate Professor, Supervisor of Postgraduate

E-mail: huanswu@jxau.edu.cnPhone number: 18458219873

Education andWorking Experience

Sep 2008- Jun 2012 Jiangxi Agricultural University Undergraduate

Sep 2012- Mar 2019 Zhejiang University PhD

Jun2019- Present College of Animal Science and Technology, Jiangxi Agricultural University Assistant Professor

Summary

My research is dedicated to animal viruses infections and their interactions with variable hosts, mianly aboutthereplication mechanism, immunology，pathogenesis and antiviralstrategy ofavian virus and other RNA viruses.

Research Project (Person in Charge):

1. National Natural Science Foundation of China “The molecular mechanism by which phosphatase PP2A-B56α dephosphorylates ribonucleoprotein (RNP) to inhibit IBDV replication” (grant32373010)500,000, 2024-2027.

2. National Natural Science Foundation of China “Analyzing the molecular mechanism of cyclin-dependent kinase CDK1 phosphorylating the infectious bursal disease virus (IBDV) VP1 protein.” (grant 32002288)300,000, 2021-2023.

3. National Natural Science Foundation ofJiangxiprovince “Study on the mechanism by which Ubc9 phosphorylation promotes IBDV replication” (grant 20232BAB205063)200,000, 2024-2027.

4. National Natural Science Foundation ofJiangxiprovince “Research on the dephosphorylation modification mechanism of IBDV ribonucleoprotein (RNP)” (grant20232ACB205015)200,000, 2023-2026.

5. National Natural Science Foundation ofJiangxiprovince “Research on the dephosphorylation modification mechanism of IBDV ribonucleoprotein (RNP)” (grant20232ACB205015)200,000, 2023-2026.

6. National Natural Science Foundation ofJiangxiprovince “Study on the mechanism by which the selective autophagy receptor optineurin targets VP1 to inhibit infectious bursal disease virus replication” (grant 90191087907)60,000, 2020-2023.

Research Achievement (Communication/First)：

[1]Huansheng Wu, Liuyuan Shi, Yina Zhang, Xiran Peng, Tuyuan Zheng, Yahui Li, Boli Hu, Xiaojuan Zheng, Jiyong Zhou.Ubiquitination Is Essential for Avibirnavirus Replication by Supporting VP1 Polymerase Activity[J]. Journal of Virology, 2019, 93(3): 1-18. (SCI, IF: 5.4)

[2] Huansheng Wu, Hui Yang, Gang Ji, Tuyuan Zheng, Yina Zhang, Tingjuan Deng, Xiaojuan Zheng, Jiyong Zhou, Boli Hu.SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1[J]. Journal of Virology, 2019, 93(7): 1-20. (SCI, IF:5.4)

[3] Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen,Huansheng Wu.Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication[J]. Journal of Virology, 2023, 97(1): 1-20. (SCI, IF:5.4)

[4] Xifeng Hu, Zheng Chen, Xiangdong Wu, Qiuling Fu, Zhen Chen, Yu Huang,Huansheng Wu.PRMT5 facilitates infectious bursal disease virus replication through arginine methylation of VP1[J]. Journal of Virology, 2023, 98(2): 1-18.(SCI, IF:5.4)

[5] Yu Li, Ning Jiang, Yaqing Mao, Wenbo Zhang, Jing Xiao, Xiangdong Wu,Huansheng Wu.Chicken optineurin suppresses MDA5-mediated interferon β production[J]. Poultry Science, 2020, 10(1):2-11. (SCI, IF:4.4)

[6] Qinghua Zeng, Jingjing Cao, Fei Xie, Lina Zhu, Xiandong Wu, Xifeng Hu, Zheng Chen, Xiaoqing Chen, Xiangzhi Li, Cheng-Ming Chiang,Huansheng Wu.CRISPR-Cas9-mediated chicken prmt5 gene knockout and its critical role in interferon regulation[J]. Poultry Science, 2024, 16(6): 9-19. (SCI, IF:4.4)

[7] Xifeng Hu, Zheng Chen, Xiangdong Wu, Zhen Ding, Qinghua Zeng,Huansheng Wu. An Improved, Dual-Direction,Promoter-Driven, Reverse Genetics System for the Infectious Bursal Disease Virus (IBDV) [J]. Viruses-Basel, 2022,14(1396): 2-13. (SCI, IF:5.8)

[8] Zhixuan Xiong, Jingjing Cao, Ke Wang, Yuling Yang, Ying Hu, Jiangjiang Nie, Qinghua Zeng, Yu Hu, Lina Zhu, Xiangzhi Li,Huansheng Wu. Characterization and functional analysis of chicken CDK protein[J]. Poultry Science, 2024,103(7):10-20. (SCI, IF:4.4)

[9] Zhixuan Xiong, Jingjing Cao, Mengchen Xiu, Aiying Li, Xiangzhi Li, Youming Zhang, Qinghua Zeng, Ying Hu, Yuling Yang, Huansheng Wu.Chicken PRMT3 facilitates IBDV replication[J]. Poultry Science, 2024,103(9):12-23. (SCI, IF:4.4)