Personal Data

Name: Zheng ChenGender: Male

Day of birth: 1986.02Policital status: Party Member of CPC

Career: Associate Professor, Supervisor of Postgraduate

E-mail: chenzheng@jxau.edu.cnPhone number: 13554295679

Working Experience

Jul 2016- Jul 2019 Huazhong Agricultural University PostDoctor

Sep2019- Present College of Animal Science and Technology, Jiangxi Agricultural University Assistant Professor

Summary

My research is dedicated to animal viruses infections and their interactions with variable hosts, mianly aboutthereplication mechanism, immunology，pathogenesis and antiviralstrategy of Japanese encephalitis virus and other RNA viruses.

Research Project (Person in Charge):

1. National Natural Science Foundation of China “Study on the mechanism of PKM2-dependent glycolysis regulates JEV induced neuronal cells pyroptosis” (grant 3 2360909) 320,000, 2024-2027.

2. National Natural Science Foundation of China “Study on the mechanism of NOD1 regulating neuroinflammation induced by Japanese encephalitis Virus” (grant 31802209)250,000, 2019-2021.

3. National Key Research and Development Program of China “Research on the Surveillance and Traceability of Alien Animal Diseases in Border Areas” (grant 2017YFD0501803)490,000, 2017-2021.

4. National Natural Science Foundation ofJiangxiprovince “Study on the mechanism of CYLD regulates JEV induced nerve cell pyroptosis” (grant 20232BAB205063) 100,000, 2023-2026.

5. National Natural Science Foundation ofJiangxiprovince “Interaction between JEV NS5 protein and host ENO1 protein and its regulatory mechanism for viral replication” (grant 20202BAB215011)60,000, 2020-2021.

6. China Postdoctoral Foundation project “JEV NS3 interacts with host RPS11 protein and its regulatory mechanism for viral replication” (grant2016M602322 ) 50,000, 2017-2018.

Research Achievement (Communication/First)：

[1] Xifeng Hu^#,Zheng Chen^#, Xiangdong Wu, Zhen Ding, Qinghua Zeng, Huansheng Wu, An Improved, Dual-Direction, Promoter-Driven, Reverse Genetics System for the Infectious Bursal Disease Virus (IBDV), Viruses. 2022,6;14(7):1396. (SCI, IF: 5.818)

[2] Zheng Chen, Xifeng Hu, Xiangdong Wu, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Jingyi Yin, Huansheng Wu, Development and Primary Application of an Indirect ELISA Based on Rep Protein to Analyze Antibodies against Porcine Cocirvirus-like Virus (PCLV), Viruses. 2022,6;14(7):1398. (SCI, IF: 5.818)

[3] Zheng Chen, Zikai Zhao, Yixin Liu, Muhammad Imran, Jing Rao, Ning Cai, Jing Ye, Shengbo Cao, Nucleotide-Binding Oligomerization Domain 1 (NOD1) Positively Regulates Neuroinflammation during Japanese Encephalitis Virus Infection, Microbiol Spectr. 2022,6;10(3):e0258321. (SCI, IF: 9.043)

[4] Zheng Chen^#, Jinfeng Chen^#, Xiaodong Wei, Huiying Hua, Ruiming Hu, Nengshui Ding, Jinhua Zhang, Deping Song, Yu Ye, Yuxin Tang, Zhen Ding, Shaoyong Ke, Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro, Viruses. 2021,12;13(12):2527. (SCI, IF: 5.048)

[5] Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao,Zheng Chen*, Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation andneuronal cell damage, Virulence. 2021,12(1): 968-980 (SCI, IF: 5.882)

[6] Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song1, Huanchun Chen, Shuhong Zhao, Shengbo Cao, Activation of Neuronal N-Methyl-D-Aspartate Receptor Plays a pivotal Role in Japanese Encephalitis Virus-induced Neuronal Cell Damage, Journal of Neuroinflammation. 2018.8, 15(1):238. (SCI, IF: 5.193)

[7] Chen, Zheng; Ye, Jing; Ashraf, Usama; Li, Yunchuan; Wei, Siqi; Wan, Shengfeng; Zohaib, Ali; Song, Yunfeng; Chen, Huanchun; Cao, Shengbo*, MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1, Journal of Virology, 2016.4, 90(7): 3722~3734. (SCI, IF: 4.663)

[8] Muchuan Yu, Jing Ye, Shengbo Cao, Xueqin Liu, andZheng Chen*, Production and Characterization of Monoclonal Antibodies Against Gp Protein of Ebola Virus, Monoclonal antibodies in immunodiagnosis and immunotherapy. 2020 Feb;39(1):12-16.

[9] Jing Rao, Jing Ye, Shengbo Cao, Xueqin Liu, andZheng Chen*, Production and Characterization of Monoclonal Antibodies Against N Protein of Rift Valley Fever Virus, Monoclonal antibodies in immunodiagnosis and immunotherapy. 2021 Apr;40(2):60-64.

[10]Zheng Chen, Lin Shao, Jing Ye, Yongmao Li, Shaomei Huang, Huanchun Chen, Shengbo Cao, Monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus, Hybridoma (Larchmt). 2012,4;31(2):137-41.